What Is SAM-e / S-Adenosyl Methionine?
S-Adenosyl Methionine (SAM, SAMe or SAM-e) is an amino acid. SAM-e was discovered in 1952 in Italy, where the highest quality SAM-e is currently manufactured. Until recently, SAM-e was exceedingly expensive to produce, and therefore unavailable to the public, although it is fairly well studied. It is manufactured in the brain from another amino acid, methionine. SAM-e is the most active methyl-donor in your body, meaning it donates methyl groups to other chemical compounds in your body including neurotransmitters, changing them into other compounds. SAM-e is then "recycled" through an ongoing re-methylation process - more on this below.
Why Buy Our SAM-e?
This is the original SAM-e, S-Adenosyl-Methionine tosylate disulfate, as developed in Italy and patented in the US. The manufacturing of this product is extremely difficult; it must be produced in a dry environment and transported packed in dry ice. It is then stabilized and double-enteric coated. This coating ensures that it is absorbed through the small intestine, since SAM-e is destroyed in the stomach. Our SAM-e uses the Italian-made raw material, and is manufactured and packaged in the United States with minimal use of fillers and excipients. Our SAM-e is also immediately packaged in individual blister cards to reduce oxidation and ensure maximum stability and freshness.
SAM-e Improves Mood
The brain of a healthy person usually manufactures all the SAM-e it needs from methionine, but S-Adenosyl Methionine production may impaired in some people.1 Supplementation with SAM-e has been shown to increase levels of serotonin, dopamine and phosphatides, and improve serotonin and dopamine receptor site binding.2 Interestingly, treatment with antidepressant drugs that results in improved mood (as determined by a 50% improvement in the Hamilton Depression Inventory) usually also results in increased levels of SAM-e, regardless of the drug used.3
Perhaps the most striking aspect of supplementation with SAM-e, is its rapid onset of action. SAM-e has been shown to have fewer side effects and a more rapid onset of action than tricyclics.1
SAM-e and Joints
Here is what we know:
- SAM-e plays an important role in cartilage formation and repair.
- In in-vitro studies, SAM-e has been shown to increase the blood levels of proteoglycans - the starting point of cartilage formation.4
- SAM-e has been shown in a number of studies to bring arthritis pain relief comparable to that of the oft-prescribed NSAID's, naproxin and piroxicam - without their side effects.5,6
In a study performed in 1990 at the Instituto de Docencia e Investigaciones Biologicas, in Buenos Aires, Argentina, arthritis was induced in the right knee of 24 rabbits. The rabbits were divided into 3 groups and treated intramuscularly with 30, 60 or 0 (diluent only) mg of SAM-e. After 12 weeks the knees were examined and it was found that the greater the amount of SAM-e given to the rabbit, the greater the concentration of proteoglycans was found in the cartilage8.
Important SAM-e Precautionary Information
SAM-e breaks down into a potentially harmful substance called homocysteine, which is strongly correlated with heart disease when left to build up within your cells. But, SAM-e does NOT have to turn into a toxic build-up of homocysteine. With the proper level of B-complex vitamins (especially B-6, B-12 and folic acid, which are all methyl-donors), homocysteine is re-methylated into beneficial methionine (used to produce S-Adenosyl Methionine) or converted to the antioxidant glutathione (also good), and a build-up of homeocysteine is prevented.
IMPORTANT: If you plan on taking SAM-e, you would be well advised to also supplement with B vitamins. This will ensure good results and prevent homocysteine build-up.
Possible Side Effects with SAM-e
Oral supplementation of SAM-e can cause nausea and vomiting in some people, so it is recommended that supplementation be graduated. Start with one 200mg tablet per day. That may be enough. After a couple days, increase to 200mg twice a day, and if needed, you can increase to 400mg twice a day on the 5th or 6th day. Only increase to 400mg three times a day after about 2 weeks, and finally, 400mg four times a day after about 3 weeks.
People suffering from bipolar disorder should not take SAM-e, as its rapid antidepressant effects can lead to manic episodes.
Try Our Premium SAM-e Today
Both sizes of our SAM-e are packaged in individual blister cards to ensure maximum freshness and minimized oxidation.
200mg S-Adenosyl-Methionine tosylate disulfate (100mg biologically active SAMe)
30 individually sealed enteric-coated tablets
400mg S-Adenosyl-Methionine tosylate disulfate (200mg biologically active SAMe)
30 individually sealed enteric-coated tablets
Small SAM-e, 200mg/100mg, 30 Tablets:
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Supplement Facts
Serving Size: 1 Tablet
Servings per container: 30 |
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Other ingredients: Microcrystalline cellulose, magnesium stearate, sodium starch glycolate, silica, enteric coating.
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Large SAM-e, 400mg/200mg, 30 Tablets:
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Supplement Facts
Serving Size: 1 Tablet
Servings per container: 30 |
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Other ingredients: Microcrystalline cellulose, magnesium stearate, sodium starch glycolate, silica, enteric coating.
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