What Is SAM-e / S-Adenosyl Methionine?
S-Adenosyl Methionine (SAM, SAMe or SAM-e) is an amino acid. SAM-e was discovered in 1952 in Italy, where the highest quality SAM-e is currently manufactured. Until recently, SAM-e was exceedingly expensive to produce, and therefore unavailable to the public, although it is fairly well studied. It is manufactured in the brain from another amino acid, methionine. SAM-e is the most active methyl-donor in your body, meaning it donates methyl groups to other chemical compounds in your body including neurotransmitters, changing them into other compounds. SAM-e is then "recycled" through an ongoing re-methylation process - more on this below.
SAM-e Improves Mood
The brain of a healthy person manufactures all the SAM-e it needs from methionine, but S-Adenosyl Methionine production is impaired in people who are depressed.1 Supplementation with SAM-e increases levels of serotonin, dopamine and phosphatides, and improves serotonin and dopamine receptor site binding.2 Interestingly, treatment with antidepressant drugs that results in improved mood (as determined by a 50% improvement in the Hamilton Depression Inventory) usually also results in increased levels of SAM-e, regardless of the drug used.3
Perhaps the most striking aspect of supplementation with SAM-e, is its rapid onset of action. SAM-e has fewer side effects and has a more rapid onset of action than tricyclics.1
SAM-e and Arthritis
Here is what we know:
- SAM-e plays an important role in cartilage formation and repair.
- In in-vitro studies, SAM-e has been shown to increase the blood levels of proteoglycans - the starting point of cartilage formation.4
- SAM-e has been shown in a number of studies to bring arthritis pain relief comparable to that of the oft-prescribed NSAID's, naproxin and piroxicam - without their side effects.5,6
In a study performed in 1990 at the Instituto de Docencia e Investigaciones Biologicas, in Buenos Aires, Argentina, arthritis was induced in the right knee of 24 rabbits. The rabbits were divided into 3 groups and treated intramuscularly with 30, 60 or 0 (diluent only) mg of SAM-e. After 12 weeks the knees were examined and it was found that the greater the amount of SAM-e given to the rabbit, the greater the concentration of proteoglycans was found in the cartilage8.
Why Buy Our SAM-e?
This is the original SAM-e, S-Adenosyl-Methionine tosylate disulfate, as developed in Italy and patented in the US. The manufacturing of this product is extremely difficult; it must be produced in a dry environment and transported packed in dry ice. It is then stabilized and double-enteric coated. This coating ensures that it is absorbed through the small intestine, since SAM-e is destroyed in the stomach.
Important SAM-e Precautionary Information
SAM-e breaks down into a potentially harmful substance called homocysteine, which is strongly correlated with heart disease when left to build up within your cells. But, SAM-e does NOT have to turn into a toxic build-up of homocysteine. With the proper complement of B-complex vitamins (especially B-6, B-12 and folic acid, which are all methyl-donors), homocysteine is re-methylated into good old methionine (used to produce S-Adenosyl Methionine) or convert to the antioxidant glutathione (also good), and a build-up of homeocysteine is prevented.
IMPORTANT: If you plan on taking SAM-e, you would be well advised to supplement with B vitamins also. This will ensure good results and prevent homocysteine build-up.
Possible Side Effects with SAM-e
Oral supplementation of SAM-e can cause nausea and vomiting in some people, so it is recommended that supplementation be graduated. Start with one 200mg tablet per day. That may be enough. After a couple days, increase to 200mg twice a day, and if needed, you can increase to 400mg twice a day on the 5th or 6th day. Only increase to 400mg three times a day after about 2 weeks, and finally, 400mg four times a day after about 3 weeks. People suffering from bipolar disorder should not take SAM-e, as its rapid antidepressant effects can lead to manic episodes! Also, see the precautionary note above regarding homocysteine.
IMPORTANT: We recommend supplementing with a complete Vitamin B Complex vitamin when taking SAMe.
Place Your Wholesale Order for SAM-e Today
Bottle: 30 tablets, 200mg S-Adenosyl-Methionine tosylate disulfate each
MSRP: $19.95 
Our Wholesale Price: $10.95
Volume Discount Price: $8.76
Box: 30 blister-wrapped tablets, 400mg S-Adenosyl-Methionine tosylate disulfate each
MSRP: $32.95
Our Wholesale Price: $17.95
Volume Discount Price: $15.60
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